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The slight decrease of inward current amplitude associated with the significant increase of the membrane capacitance resulted in a clear reduction of inward current densities (i.e., current amplitude divided by membrane capacitance) after retinal detachment (Fig. 4D).
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This decreased membrane capacitance may result from the observed reduction in the number of microvilli and from the shrinkage of cells as observed by electron microscopy and flow cytometry.
For the fully activated conductance of I f, Kurata et al. [ 77] used the value of 12 nS of van Ginneken and Giles [ 39], which, with their membrane capacitance of 32 pF, results in a normalized value of 0.375 nS/pF in the equation for I f : (27) I f = y 2 × 0.375 × (V m + 26.02 ), in which I f is again expressed in pA/pF and V m in mV.
We verified that the two methods of measuring membrane capacitance described above gave similar results (data not shown).
The obtained results demonstrated that membrane capacitance affects the noise by amplifying the noise of the applied voltage.
As a result, increase in the membrane capacitance is recorded.
A train of ten depolarization steps from −70 mV to 0 mV evoked larger responses in p38δ Δ/Δ than in control β cells, resulting in a 2-fold larger increase of membrane capacitance in p38δ Δ/Δ cells.
In order to interpret the results obtained so far, we assumed that changes in membrane capacitance in ZmSUT1 expressing oocytes were associated with charge movements inside the transporter.
Regarding the phase of the force generated by the OHC relative to the deflection of the hair bundle, a phase delay of 90 degrees is suggested in the high frequency range; this delay is probably resulting from low-pass filtering at the membrane due to membrane resistance and membrane capacitance [ 16] (see Appendix).
Membrane capacitance (Cm) was 5.9±0.3 pF and series resistance after electronic compensation of up to 70% (Rs) was 2.5±0.3 MΩ, resulting in voltage-clamp time constants of 15±2 µs (n = 21).
This point is now discussed in the sixth paragraph of the Results and Discussion section as follows: 'This augmentation of the IHC resting membrane capacitance was about 50 times larger than the size of the RRP evoked by membrane depolarization.
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