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Moreover, Bag6* was preferentially detected in the membrane bound pool of Bag6 in USP13-depleted cells.
Significantly, membrane targeting of Warts together with Mats was sufficient to reduce tissue growth in Drosophila[ 67], suggesting that the membrane bound pool of LATS1/2 might be physiologically relevant as well.
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This is important because the labile membrane bound pool may be a consequence of this difference.
Moreover, the differences between the human and the fish protein may be at the basis of the different membrane bound pools.
In this case, neurons were not permeabilized with saponin prior to fixation; thus, the images indicate both membrane bound and cytosolic pools of VAC14.
Combining modelling, an improved FRAP methodology and direct semi-quantitative analysis of bleaching suggests the existence of two membrane-bound Dystrophin populations with widely differing bound lifetimes: a stable, tightly bound pool, and a dynamic bound pool with high turnover rate that exchanges with the cytoplasmic pool.
In addition, when using a dominant positive mutant of Rab4 that is permanently attached to the membranes, Van Der Sluijs and collaborators, demonstrated that the membrane-bound pool of Rab4 is targeted by a mitotic kinase.
While ProSAP2/Shank3 in a soluble pool contributes to the potential of the postsynapse to undergo activity-dependent changes, the PSD bound pool determines the actual transsynaptic signal.
Experimentally, CDRs have been associated with membrane bound activators of actin polymerization of concave shape.
CD59 is a naturally occurring membrane bound inhibitor of MAC formation.
Metazoan membrane bound ACs are composed of two membrane domains, each consisting of six transmembrane helices.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com