These drugs were designed to block farnesylation of RAS and therefore prevent its localization to the membrane and subsequent signaling.
Currently, the specific cellular receptors or proteins involved in poxvirus fusion with the plasma membrane and subsequent cellular entry are not known.
AD-related cognitive impairment, synaptic loss and neurodegeneration result from interactions of Aβ oligomers with the synaptic membrane and subsequent activation of pro-apoptotic signalling pathways.
We used a biotin capture technique based on reaction with free amines to selectively purify membrane proteins to determine whether redox stress also exerted any effect on the translocation to the membrane and subsequent association with the extracellular face.
Mason-Pfizer monkey virus (M-PMV) Gag polyproteins assemble into immature capsids within the cytoplasm of the host cells; however, their processing occurs only after transport to the plasma membrane and subsequent release.
Membrane-based technologies are increasingly used for water and wastewater treatment; however, biofouling, the adhesion of microorganisms to the membrane and subsequent formation of biofilm, remains a major obstacle in real applications.
Experimental evidence shows that the mechanism of pore formation by actinoporins is a multistep process, involving binding of the water-soluble monomer to the membrane and subsequent oligomerization on the membrane surface, leading to the formation of a functional pore.
For SFV, acidification allows insertion of viral spike glycoproteins into the endosomal membrane and subsequent delivery of the nucleocapsid into the cytoplasm [32].
This exocytic process involves fusion of multivesicular bodies (MVBs) with the plasma membrane and subsequent release of the intraluminal vesicles as exosomes [12].
Membrane proteins that fail to fold correctly are subject to ER associated degradation (ERAD), which involves their extraction from the membrane and subsequent proteasome-dependent destruction.
Taken together these studies suggest that endogenous KCNE1 and KCNE3 are important for the regulation of Kv12.2 trafficking to the plasma membrane and subsequent channel activation.
