Sentence examples for membrane and functional from inspiring English sources

The synthesis of orotic acid is catalyzed by dihydroorotate dehydrogenase (DHODH), an enzyme located in the inner mitochondrial membrane, and functional connection to the respiratory chain via ubiquinone ensures efficient oxidation of dihydroorotate [2].

Col4a1 mutant mice also have thinning and splitting of the glomerular basement membrane and functional renal pathology, including microalbuminurea and hematuria (80).

These data in oocytes strongly suggest that S/G6′-heteropentamers of GLIC are assembled, inserted in the membrane and functional with modified properties.

Activation of Wnt signalling leads to phosphorylation of LRP-5/6, recruitment of Axin and Dvl (Dishevelled 1) to the plasma membrane, and functional disruption of the β-catenin degradation complex.

The presence of cell membrane and functional ET-1 receptors in SW480 and HT-29 cells was evaluated using I-ET-1 binding and the phosphorylation of ERK, a known intracellular mediator of ET-1.

For this we show here our work on two cell lines of different physiological functions used in our laboratory, that have previously been shown to exhibit regions of higher and lower membrane order, and functional cell membrane protrusions such as macrophage filopodia.

The copper stress can induce cell membrane lipid peroxidation and membrane structure and functional damage.

Further studies are needed to evaluate the effect of ω-3 PUFAs on the conformational changes of membrane receptors and functional changes of cell membrane receptors.

In addition to using the method in support of a membrane structural and functional biology program, the Membrane Structural and Functional Biology (MS&FB Groupp is active in further developing the technique with a view to bringing it to a wider audience and to making it more generally accessible and useful.

Interestingly, MFS transporter CaMdr1p shows no such selectivity towards raft lipid constituents and remains fully membrane localized and functional in cells where sphingolipid or ergosterol biosynthesis is compromised [9].

EMT plays a role in PD-related peritoneal membrane morphological and functional alterations [ 19, 20].