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ABC transporters are generally located in the cellular plasma membrane and function in normal biology to protect cells from harmful toxins and xenobiotics.
This family is known to interact with integrins at the plasma membrane and function as transcriptional coactivator after nuclear translocation [ 5].
SUN (Sad1p/Unc-84) domain proteins reside in the inner nuclear membrane and function with other proteins to form a physical link between the nucleoskeleton and the cytoskeleton.
It has been known that Bcl-2 family members reside in the ER membrane and function principally at the mitochondrial outer membrane, so they may influence homeostasis and apoptosis from the ER as well [ 35, 36].
These regulators also termed adaptors localize at the Golgi, endosomal or plasma membrane and function in pairs of proteins from different subfamilies such as the ANTH Sla2/HIP1 and the ENTH Ent1-2/Epsin1,2,3 in endocytosis.
The now-activated JAK2 phosphorylates STAT3, which forms homodimers, can cross the nuclear membrane and function as a transcription factor, inducing various genes including genes involved in the cellular transformation process [ 15].
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Our analyses revealed that Trak1 interacts and colocalizes with mitofusins on the outer mitochondrial membrane and functions with mitofusins to promote mitochondrial tethering and fusion.
Exogenous sucrose was sensed by a sensor localized on the plasma membrane and functioned as an enhancer to promote OsSUT2 expression.
Magnesium is involved in the stabilisation of the cellular membrane and functions as a coenzyme.
Notably, this mutant still localizes to the surface membrane and functions in a nominally normal fashion.
SDH is located on the inner mitochondrial membrane and functions in the mitochondrial respiratory chain and the Krebs cycle.
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