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This situation allows membrane aggregation induced by one peptide interacting with two membranes or by homotopic peptide dimerization (Fig. 5B).
The effects on membrane aggregation induced by both peptides in the presence of DRMs from BHK-21 and VERO cells were different, reflecting a difference in lipid composition.
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The enhanced emission intensity was attributed to aggregation induced emission.
Vesicle aggregation induced by Ebola fusion peptide was evaluated by dynamic light scattering (DLS).
GSK3 activity can thus modulate protein aggregation induced by puromycin.
This finding contrasts with the report describing the penetratin induced membrane aggregation with DMPG and DOPG LUVs [24].
The non-amphipathic basic peptides are able to induce membrane aggregation and tube formation but do not form pores and show low cell toxicity.
The basic residues in the surface must be in the right positions (i.e. in all directions) to induce membrane aggregation.
This Rab-induced membrane aggregation was a reversible membrane tethering reaction that can be strictly controlled by the membrane recruitment of Rab proteins on both apposing membranes.
On the contrary, the liquid disordered LUV, notably in the presence of PG, have shown membranes deformed by Penetratin interaction, confirming that the fluidity is required to observe the peptide induced deformations and high levels of membrane aggregation.
Based on experiments with PEG-conjugated lipids the authors found that the transition is driven by membrane aggregation, which is consistent with our model in which the α helix induces the membrane adhesion.
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