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Born-again Protestant group membership at baseline was associated with greater atrophy in the left and right hippocampus compared with non born-again Protestant group membership (left: b = −0.15, P = .046; right: b = −0.15, P = .050).050
Catholic group membership (n = 22) (b = −0.22, P = .046) and no religious group membership at baseline (n = 19) (b = −0.28, P = .046) were also associated with greater atrophy in the left hippocampus over time compared with non born-again Protestant group membership.
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Model 1: adjusted for cohort membership, sex and age at baseline.
Outcome measures at baseline, group membership and time will be included as fixed explanatory variables.
Grouping patients according to results of combinations of several clinical tests and assessment of pain was investigated in a pilot study classifying primary care patients into 10 diagnostic classes based on a clinical examination, which found that membership of a diagnoctic class at baseline was associated with the total number of days with LBP over three months [ 76].
The transition probability matrices are estimated by a logistic regression for nominal response (e.g. probability of health profile membership at T1, conditional on baseline health profile membership) [ 33, 54].
The evaluation of the primary outcome will be through an intention-to-treat (ITT) analysis using a logistic regression, allowing for centre membership and severity of command hallucinations at baseline.
The incidence rate was estimated by incident cases of diabetes identified during the calendar year of 2010 divided by the population at risk (n = 1,912,916), which excluded those with known (prevalent) diabetes at baseline or incomplete membership in the previous year (precluding ability to reliably ascertain if they joined with pre-existing diabetes).
We included type 2 diabetic subjects from the Registry who were aged ≥60 years at baseline (1 January 2004) and who had continuous Kaiser membership and pharmacy benefits for at least 12 months before baseline.
Membership of emotion profiles were predicted by autonomous and controlled motivation assessed at baseline.
Age cohort membership was included in all analyses to control for variation in age at baseline when the predictors were assessed.
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