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Moreover, TNFRSF17 can combine with TRAF family members to induce cell apoptosis and proliferation [18].
It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation.
However, at low doses neither Dox nor PL elicited the activity of these caspase family members to induce apoptosis.
This observation suggests that cadherins can activate signaling pathways which are similar to or partially overlap with signaling pathways activated by IgSF members to induce Ca2+ influx at the cell surface.
This may occur partly through interaction with FoxO3a/FKHRL1, both of which are indispensable for the activation of the pro-apoptosis protein Bim (Bcl-2-interacting mediator of cell death), or by cooperating with SMAD protein family members to induce the TGF-β/SMAD pathway in other ways [ 6, 7].
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The New Yorker, April 17 , 1926 P. 11Apropos of skating carnival, we wonder if any other organization in N. Y. beside N. Y. Skating Club at Iceland, 52nd Street, could induce members to get up at seven o'clock in winter?
The possibility to target Bcl-2 famembersmbers proteins to induce apoptosis in cancer cells has been studied for many years now and particular attention has been given to BH3 only proteins in designing drugs that would mimic their pro-apoptotic functions.
Finally, Grau et al have demonstrated that CBX2 is the only human CBX family member able to induce chromatin compaction (Grau et al, 2011).
The BBC paid more than £100,000 each to 11 members of staff to induce them to move to the organisation's new broadcasting centre in Salford.
Moreover, the ability of several family members (death receptors) to induce death (mainly via apoptosis) represents a promising target for cancer therapy.
In addition to miR-125a-5p, other miR-125 family members were shown to induce drug resistance (Zhou et al, 2010) and regulate cell death pathways, such as NF- κB (Kim et al, 2012) and p53 (Leotta et al, 2014).
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