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In addition to wildtype MYCN, we studied a mutant MYCN with a deletion within MYC homology box II (MBII), a conserved region among MYC family members shown to be essential for many of MYC functions such as the regulation of some target genes, transformation, proliferation, and apoptosis [34], [39] [41].

Other families with members shown to have roles in defense against pathogens are the subtilisin-like serine proteases and the pathogen-related PR1 family [ 36].

Another, FFT4.2b (snp4_493905), was tightly linked to the candidate gene Light Responsive Bric-a-Brac3, At4g01160, with family members shown to interact with phytochrome B and D diurnal and seasonal signaling pathways (Christians et al. 2012).

Other members shown to be relevant for parasite survival upon infection (as CRP or GP85, see genes TcCLB.511129.40, TcCLB.511911.60 and TcCLB.506455.30 in the Additional file 4), are also overexpressed in MT [ 33, 34].

The power of the described approach was validated by the Pearson Correlation analysis of the MADS-BOX genes which correctly identified most members shown to belong to the major network controlling floral patterning and differentiation.

Similar(53)

Among the four DCLs in Arabidopsis, DCL2 was the first family member shown to play a role in antiviral defense against Turnip Crinkle Virus (TCV).

Forced expression of miR-200 family members was shown to prevent a TGF-β induced mesenchymal phenotype [105], and block tumorigenicity of CD24-CD44+ CD24-CD44+.

In Arabidopsis, both the CII members were shown to be induced by HT.

MiRNAs associated with N- myc amplification such as miR-17-92 miR-17-92 miR-17-92 shown to be assoclusterwith NB tumembersicity.

Recently, WUSCHEL (WUS -related homeobox (WUS -related family members were shomeoboxpromote AR formation in transgenic hybrid poplar [ 17].

In general, isoflavones are considered to be phytoestrogens, because some members were shown to bind to transactivate estrogen receptors and to initiate gene expression [ 9].

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