Because of the severity of disease, cases are usually sporadic with no other affected family members, precluding linkage analysis as a means to gene discovery.
None of the other groups contain characterized members precluding judgment of functional diversity within superfamily G. Supergroups H and I are adjacent clans containing only one functionally characterized member, AtPTR3 (in supergroup I).
Indeed, genetically altering BH3-only protein levels in mice resulted in complex phenotypes due to multiple interactions between family members, precluding firm conclusions as to which BH3-only proteins are direct activators.
However, the complexity of the NFAT and NF-κB families, together with the regulation of genes by both transcriptional factor members precludes ascribing the described PARP-1-dependent genes to a unique and direct effect on NFAT or NF-κB dependent transcriptional activity.
In addition to the disparity of molecular interactions and biologic functions that have been ascribed to the PLSCR proteins, a unifying concept of the functional properties of the PLSCR family has also been hindered by the absence of any solved or predicted molecular structure for its members, precluding an attempt to gain insight into protein function from protein structure.
The report points out that others who had more tangential connections to Mr. Madoff, including anyone who attended the wedding of his niece to a S.E.C. staff member, were precluded from any involvement in the case.
The third group, the low adherence group (LA, <60% session participation), consisted of five members only, precluding follow-up evaluation due to very different comorbidities, for example, diabetes, peripheral artery disease, cardiovascular disease, chronic heart failure and leg amputation.
69 70 76 95 Existing individual and family problems (such as patients' symptoms being directed at family members 62) also precluded family involvement.
Germany agreed to relinquish the Deutsche Mark on the condition that the new currency area would not lead to direct or indirect socialisation of its members' debt, thus precluding any financial assistance from EU funds for states facing bankruptcy.
Helping our friends and our family members does not preclude helping women and babies in Africa or victims of the Tsunami in Indonesia or the earthquake in Haiti.
