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Genes included in this group were those encoding for chemokines and those encoding members of the complement system.
Gene expression of members of the complement cascades was upregulated (p<10−8) (Table 1; Fig. 1 B and 2 A) in the RPE/choroid of old animals.
Genes encoding innate immunity-associated proteins also feature prominently in this functional class including several members of the complement system, C20orf114 (a member of the PLUNC family of host defense proteins) and toll-like receptor 1 (TLR1).
Genetic dissection in mice has identified the importance of several members of the innate immune system in the so-called priming phase of PH, including IL-6 and members of the complement system.
Using SigPathway, additional members of the complement pathway C8, CFH and CFD were identified.
There are also members of the complement (three genes) and the TNF family (TNFβ/LTα) showing signatures of balancing selection.
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where h k s are the ELP coefficients as defined in (36) and Appendix Appendix 1, r is a member of the complement of Λ, and the index additions are in mod(n).
C3, a member of the complement system of serum proteins, is a major component of the innate immune and inflammatory responses.
C1 is the first member of the complement system.
CFHR5 is a member of the complement factor H CFHH) family, a group of highly related proteins encoded by genes located within the regulator of complement activation (RCA) gene cluster on chromosome 1.
In this study, we also addressed the following putative malignancy-associated antigens, based on published data (Table 2): ICAM-1 (CD54), endoglin (CD105), CD109 (a GPI-linked member of the complement superfamily), CD137 (tumour necrosis superfamily factor 90), CXCR7 (C-X-C chemokine receptor 7) and CD276 (a member of the B7 family of costimulatory molecules), all cell surface expressed proteins.
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