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This review points to a need for better mechanistic understanding of the effects of P on methane oxidation, and the role of traits of methanotrophic community members in regulating this process.

The role for specific SIRT family members in regulating Foxp3 acetylation levels still remains poorly understood.

Since a dominant role of anti- and pro-apoptotic Bcl-2 family members in regulating mitochondrial outer membrane permeabilization is well documented, we searched for such factors among the hit list.

A number of studies suggest the involvement of PKC family members in regulating leukaemic cell survival and proliferation.

In a study conducted by Duan et al. (2010), the role of miR-34 family members in regulating PRIMA-1 induced apoptosis was investigated.

Our data are in line with the functions of other semaphorins which act through Rho GTPases, FAK, and Src kinase family members in regulating cell spreading during neurite outgrowth, tumor progression, and vascular barrier integrity (Barberis et al, 2005; Franco & Tamagnone, 2008; Shimizu et al, 2008; Le Guelte et al, 2012).

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Together, this shows how important ERM and Merlin family members are in regulating both actin and MT cytoskeletons.

However, STAT5 is dominant over its related family member STAT3 in regulating BCL6 expression levels in T-47D and SK-BR-3 cells [ 65].

In addition, a number of ubiquitous transcription factors, such as AP1, Sp1, and the AP2 family members, are involved in regulating keratinocyte gene expression and differentiation [3].

COUP family members are involved in regulating the expression of BMP-4 during embryogenesis.

Role of the members of MAPKs in regulating defence compounds such as phytoalexins have been well documented in Arabidopsis and rice.

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