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The Principal Investigators at each HVT site agreed to sensitization meetings with site-staff and CABs to discuss participation and, with their approval, provided full lists of eligible site-staff and CAB members for sampling.
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Often Y and are missing for some members of sampled clusters.
A serum sample was available for 216 of the 237 crew members; for 5 samples the results of serology were not interpretable because of unspecific reaction in HAI test.
High-resolution genotyping identified a common haplotype of 707 kb in all affected family members for whom samples were available.
Although this sampling criterion is relatively strict, generally > 50% members were sampled for each gene family.
Informed consent was granted by all family members for obtaining biological samples.
Mean blood lead concentration in the 55 cohort members for whom plasma samples were available was lowest at 10 years of age (3.0 μg/dL) and highest at 12 months of age (9.8 μg/dL; Table 1).
New members for the panel are sampled from the general population.
HILDA is a household-based panel study which began in 2001; interviews are conducted annually for all members of the sampled households who are aged 15 years or older.
FGN and GENCAPO team members were responsible for sample and data collection and initial on-site sample processing, sequencing SAGE libraries, provided the pathological analysis of the cases, obtained informed consent and discussed the findings.
GENCAPO team members were responsible for sample collection and initial on-site sample processing, provided the pathological analysis of the cases, obtained the informed consent and discussed the findings.
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