MAPK family members are activated by phosphorylation and upon activation are translocated from the cytoplasm to the nucleus [23], [24], [25].
First, whether different pharmacological, genetic and physiological manipulations that boosts NAD+ production lead to enhanced activity of all sirtuin enzymes or whether only a few family members are activated, especially considering the fact that some sirtuins may have opposing actions?
In Texas, all 12,000 members were activated within two days of Hurricane Harvey coming ashore with Category-4 strength.
All family members are activated by hyperosmotic stress.
For instance, in [26] and [25], the cluster head is taking care of its cluster members, whereas a part of the cluster members are activated for monitoring the cluster head.
Indeed, nearly 2,000 National Guard members were activated by Gov. Pete Wilson on Wednesday evening, with nearly all in place at armories by 8 a.m.
"God has everything under control". Thousands of National Guard members are activated up and down the coast, and all road tolls in Florida have been suspended in counties with evacuations.
The MAPK family members are activated in a 3-tier kinase cascade comprising of MAPK kinase kinase (MAPKKK), MAPK kinase (MAPKK) and MAPK[17].
To determine which NF-κB members were activated in TEL-JAK2 leukemic cells, we pre-incubated nuclear extracts with specific NF-κB antibodies that either supershift or inhibit protein/DNA complexes.
Subclass IA members are activated by ligand binding of receptor tyrosine kinases (RTK), whereas Subclass IB members are activated by G protein-coupled receptors.
