The second group of three member proteins showed similar expression levels and included KIAA1143 homolog, CD73 antigen, and CRP2.
In tomato, except a few uncanonical GRAS proteins, multiple sequence analysis of tomato GRAS proteins showed that most members in this family possess a highly variable N-terminal domain, indicating the functional versatility of this gene family in tomato.
The IRG proteins showed multiple interactions in these assay systems and each family member displayed a distinct pattern of behaviour.
Furthermore, FST315 and FST288 have been shown to bind to other TGF-beta superfamily member proteins, such as BMP-6 and MBP-7 (Sidis et al. 2006), and current study did not examine the binding of FST-type proteins to other TGB-beta superfamily member proteins.
For example, exon 4 in rhoQ, which encodes ras homolog gene family, member Q protein, showed significantly lower mean log10 ratios in DBA/2J and C57BL/6J while demonstrating elevated expressions in C3H/HeJ relative to the pool of control samples suggesting that different ratios of alternatively spliced isoforms are present among the three strains.
Representative members of this family of proteins show an interesting species distribution as reported in Pfam (July, 2007).
The discovery of CCN3 provided the first evidence for a member of the CCN family of proteins showing antiproliferative activity on chicken embryo fibroblasts (CEF).
In summary, two of the three known members of the hAG family of proteins show clear relevance to breast cancer that is strengthened by their roles in Xenopus development, a significant association with ER, and putative protein-binding partners that are not only linked with cancer progression but provide opportunities for those interactions to be targeted in the development of cancer therapies.
However, some IAP family proteins show functional redundancy with other IAP family members in vivo.
The alignment of the predicted silkworm OBP-like proteins shows low average pairwise sequence identity between OBP family members.
