We further identify an axis involved in lineage specification that includes Gata2 and Ddit3, a C/ebp family member previously implicated in stress response (Zinszner et al., 1998) and described as a potential target of erythropoietin signaling in erythro-leukemic cell lines (Coutts et al., 1999).
To gain an insight into the molecular mechanisms underlying the prosurvival effect of MYD88 L265RPP, we examined its effect on the expression of Bcl-xL, which is an anti-apoptotic Bcl-2 family member previously implicated in the enhancement of survival by TLR signaling pathway involving MYD88 and NF-κB in CD4-positive T cells.
Of particular note are the putative enzymes, some likely to be involved in matrix cross-linking (two yellow family members previously implicated in eggshell integrity, a heme peroxidase, and a small-molecule oxidoreductase) and others possibly involved in matrix proteolysis or adhesion (proteins related to cathepsins B and D).
Genes such as MMP1, MMP9, IL1B, PLAU, PLAUR, and several cathepsin family members previously implicated in the pathogenesis of AAA were among the 3,274 differentially expressed genes.
Another promising candidate is GNB1, a member of the previously implicated N-methyl d-aspartic acid (NMDAR) gene pathway (26).
The role of the TRAF family member TRAF6 has been previously implicated to be necessary for full NF-κB activation in response to viral infection and cytosolic RNA [35].
In this issue of Aging, workby Chua, McCord et al. suggests that SIRT6, a member of a protein family previously implicated in promoting longevity, may function at least in part via increasing efficacy of DNA repair.
NOXs are a family of enzymes, some members of which have been previously implicated in cell proliferation and cancer.
Kil2 belongs to the group V Ptype ATPase family, and no member of this family has been previously implicated in host pathogen interactions, nor has magnesium been previously linked to intraphagosomal killing mechanisms.
Three other members of the Glypican family have been previously implicated in human disease, including cardiac conditions.
By examining multiple members of a pathway that has been previously implicated in both the genetics (13) and physiology (11) of PCOS, we have demonstrated that the presence of variants in multiple members of a single pathway may increase PCOS susceptibility.
