The 27-kDa Heat Shock Protein (Hsp27) is an actin-associated protein, predominantly expressed in skin and cells of normal estrogen target organs [ 2], whereas the HSP70 family includes constitutive (Hsc70 or Hsp73) and inducible (Hsp70 or Hsp72) members, localized within both the cytoplasm and the nucleus of all tissue cells [ 1, 3].
To test if additional Brix domain family members localize to the nucleolus and to confirm consistency in sub-cellular localization across organisms, we isolated three Drosophila homologs of this domain family (CG32253, CG11920, and CG6712).
However, several IL-1 family members localize to cell nuclei and, like HMGB1, may have dual functionality.
However, several IL-1 family members localize to cell nuclei and may regulate intranuclear processes such as transcription and RNA splicing.
Furthermore, transverse sections through the intestinal epithelium reveal that within these small cells, all the Par complex members localize in a polarized fashion apically.
In TGN compartment, Qa-SNARE group members localize in a complex (SYP41, VTI12, VPS45 and SYP61) [ 26] and all these compartments are stained by FM4-64 before this dye reaches RabF2 or GNOM- containing compartments [ 25, 26].
Certain genes, often in small gene families with 2 to 8 members, localize to the variable regions of the genomes and show high sequence diversity between the assemblage A isolates.
The analysis of the flanking gene families revealed that those which are multi-copy and whose duplication timing coincides with vertebrate emergence, typically have their members localizing to Hsa4, Hsa5, Hsa8, Hsa10 and/or Hsa2.
BmfCUG and the originally described isoform, Bmf short (BmfS), display comparable binding affinities to pro-survival Bcl-2 family members, localize preferentially to the outer mitochondrial membrane and induce rapid Bcl-2-blockable apoptosis.
Similarly, CAMSAP-tubulin stretches may function as seeds that allow microtubule regrowth (Tanaka et al., 2012; Jiang et al., 2014), and both ninein and Patronin family members localize to junctional complexes (Lechler and Fuchs, 2007; Meng et al., 2008) where they could serve anchoring functions.
