Our phylogenetic and structural analysis of vertebrate TLR1 gene family members also predicts amino acid residues likely to be important in the primary function of TLRs in the host's defense against invading pathogens.
The other human PAQR members were also predicted to have their N-termini residing in the cytosol (predictions made by Phobius [ 38]).
Several prokaryotic members of subfamily 5 are also predicted to be downstream of a Zur-binding site (Additional File 5), suggesting a role for bacterial members of subfamily 5 in the response to zinc limitation.
There is a strong evidence that Rag1, also predicted to be a member of NBS-LRR family [ 29], mounts its defense ubiquitously in surface cellular layers [ 31].
In addition, novel transcriptional regulators of vascular development, such as Yin yang 1 (Yy1), the ETS family member GABPalpha (Gabpa), or the bZIP TF MafB, were also predicted.
A Nuclear localization signal (NLS) was also predicted for all the family members.
Several families were also predicted to have the same subcellular locations for all members.
He also predicted that there would be a "huge exodus" by other party members.
It also predicted a deleterious mutation in the Fanconi Anaemia FANCA gene in all quartet members except Mother.
Analysts also predicted that c.p.m.
