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Ascorbic acid was used as an inhibitor of catechol aldehyde-based melanin formation, and the production yields of protocatechualdehyde and p-hydroxybenzaldehyde were 31.0 ± 5.6 and 24.0 ± 4.2 mg/L, respectively.
These proteases are mainly involved in the processes of melanin formation and hemolymph coagulation against the infections of foreign pathogens.
The results confirmed that disomy at chromosome 13 is correlated with both loss of melanin formation and reduced murine virulence.
However, we also discovered copy number changes for other chromosomes in strains with altered melanin formation, and the correlation with chromosome 13 was not always observed.
After growth in culture or passage through mice, subsequent strains were identified that varied in melanin formation and exhibited copy number changes for other chromosomes.
In conclusion, the tyrosinase gene of S. parasitica is required for melanin formation and transient gene silencing can be used to functionally characterize genes in S. parasitica.
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Overall, these results established a correlation between disomy at chr 13 and phenotypic traits with potential relevance to virulence and clinical outcome, i.e., melanin formation, secretion and susceptibility to fluconazole.
Fungi have sophisticated and conserved signalling cascades to sense and respond to a rapidly changing environment by regulating essential functions such as melanin formation, mating, virulence, and morphogenesis.
The yellow gene product is an extracellular protein with an as yet-uncharacterized function in dopa melanin formation or sequestration and its late pupal epidermal expression correlates strongly with melanin patterns in diverse Drosophila species (Walter et al. 1991; Wittkopp et al. 2002a, b).
AVS073 extracts and GA, used as a reference compound, suppressed UVA-augmented tyrosinase activity and mRNA and melanin formation.
Laccases belong to the multicopper oxidases, which have a wide range of catalytic activities including polyphenol degradation and synthesis, lignin degradation, and melanin formation.
Related(19)
melanin blood and
melanin distribution and
melanin capsule and
melanin tyrosine and
melanin synthesis and
melanin hemoglobin and
melanin level and
melanin coloration and
melanin layer and
melanin bone and
melanin stimulation and
melanin content and
melanin eumelanin and
melanin pigmentation and
melanin biosynthesis and
melanin production and
melanin patterning and
melanin growth and
melanin secretion and
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