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It has been postulated that atypical and melancholic depression subtypes exist in depressed fibromyalgia (FM) patients, yet no study has empirically tested this hypothesis.
Like Lamers et al. [ 35] they drew attention tot the ongoing debate on the best criteria to delineate melancholic depression from atypical depression and other depressive conditions.
Depressed fibromyalgia patients commonly experience both atypical and melancholic depressive features; however, in this study, atypical depression was 1.5 times more common than melancholic depression.
Apart from the classical syndromes characterizing euphoric mania and melancholic depression, recent literature has pointed to alternative mood states associating both manic and depressive symptoms.
We designed an extension study to examine cost benefits of psychostimulants more closely for those only with melancholic depression.
Baeken, C. et al. The impact of HF-rTMS treatment on serotonin 2A) receptors in unipolar melancholic depression.
In melancholic depression, the activities of the central glutamate, norepinephrine and central cytokine systems are significantly and persistently increased.
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Delineation of depressive sub-types (melancholic versus non-melancholic depression) proceeded according to the clinical criteria presented by Parker et al. [ 34].
It was concluded that sertraline is more effective than imipramine in the acute treatment of depressive and anxiety symptoms in patients with non-melancholic depression.
The present study examines the moderating role of global depression severity on the relation of melancholic versus non-melancholic depression to severe and non-severe levels of stress.
The acute treatment efficacy, tolerability, and effects on health-related quality of life of sertraline (50 200 mg/day) versus imipramine (75 225 mg/day) were compared in outpatients with non-melancholic depression.
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