For the MEGA analysis: model of amino acid substitution = JTT; gamma = 0.84 (obtained using ProtTest).
A mega-analysis of genome-wide association studies for major depressive disorder.
Structural magnetic resonance imaging in bipolar disorder: an international collaborative mega-analysis of individual adult patient data.
The current study was undertaken to perform an international collaborative mega-analysis of regional volumetric measurements of individual patient and healthy subject data, to optimize statistical power, detect case-control differences, assess the association of psychotropic medication usage with brain structural variation, and detect other possible sources of heterogeneity.
We then carried out a quantitative mega-analysis of studies done with post-mortem brain tissue.
Unfortunately, the CONVERGE group failed to replicate their top signals in the Psychiatric Genomics Consortium (PGC) mega-analysis of European cohorts [ 5].
The mega-analysis of any brain region included all studies on the PFC, one study on the hippocampus, and two additional studies on the anterior cingulate and thalamus.
To date, it remains unclear whether the genome-wide significant risk variants for schizophrenia in a mega-analysis of GWASs influenced GM volumes.
For example, Sandler and colleagues' mega-analysis of 48 different meta-analyses of prevention programs [ 82] identified many effective programs targeting children and adolescents, with demonstrated impacts on depression, anxiety, aggression, antisocial behaviour, violence and substance misuse.
Genome-wide significant associations of schizophrenia with eight SNPs in the CNNM2, MIR137, PCGEM1, TRIM26, CSMD1, MMP16, NT5C2 and CCDC68 genes have been identified in a recent mega-analysis of genome-wide association studies.
