Although two large RCTs did not meet their primary endpoint, several beneficial clinical effects of treatment have been shown.
He and the designers have met their primary objective, in that the DeltaWing does what it was engineered to do.
Roadmapping efforts for these innovations are increasingly failing to meet their primary goal of including technology into the strategic process of firms, regions or industries.
Over 70% of the population of Sub-Saharan Africa, mostly in the rural areas, depend on wood fuel, as firewood or charcoal, to meet their primary domestic energy requirements.
Although none of the trials met their primary endpoints, they have greatly increased our understanding of AD and the role of Aβ9.
Of five blinded and sham-controlled DBS clinical trials, however, two met their primary endpoint, two did not, and one remains unpublished3,4,5.
Although gene therapy approaches tested so far have been shown to be safe, none met their primary endpoints in phase II clinical trials designed and powered to test the efficacy of the intervention.
Both BLISS-52 and BLISS-76 international phase III trials in Systemic Lupus Erythematosus (SLE) met their primary outcomes; however, they were not designed to assess the efficacy of belimumab for the treatment of lupus nephritis (LN).
Even if several examples of translational success have been reported it is a matter of fact that clinical trials in oncology often fail to meet their primary endpoints despite encouraging preclinical data.
All phase III trials met their primary endpoints for all doses of ocrelizumab, with the exceptions of the FEATURE single infusion group and FILM, which was terminated prematurely.
