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Histologically, testes are characterized by medullary development and distinguishable testicular lobules.
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Medullary development has been observed from week 8 and distinct cortical and medullary compartments by week 16.
In the majority of these animals, renal medullary development was approximately equivalent to that of WT mice.
In thymus, correct differentiation of cortical thymic epithelial cells (cTECs) and medullary TECs (mTECs) is required for thymocyte development and selection.
Recently, it is demonstrated that Foxn1 is required for stable entry into both the cortical and medullary TEC development lineage in Foxn1 dosage-dependent manner [ 77].
In this report, we have described an improved technique for organ culture of mouse metanephric organ rudiments that is very economical of medium, shows quantitatively better development and also shows cortico-medullary zonation absent in the conventional method.
Skill Development and Marketability.
Apart from the invaginations, the FVB/N thymus was structurally normal at birth, with discrete cortical/medullary development and normal localization of epithelial subsets, endothelium, dendritic cells, macrophages, and thymocytes (Supporting Information Fig. 1).
"Economic development and social development are inseparable.
Policy Development and Coordination.
Aire mutations have been implicated in the human disease APECED, which may result from defective medullary TEC development, and/or lack of expression of tissue-specific antigens (TRAs) that result in alterations in negative selection of thymocytes (reviewed in [29]).
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