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Histological analysis of the five K5CrexRac1flox/flox mice with thymic tissue at 6 weeks revealed complete loss of the medulla compared to littermate controls (Figure 4B and 4C).
Histological analysis of tamoxifen treated K14CreERxRac1flox/flox mice revealed destruction of the medullary-cortical architecture with loss of medulla compared to littermate controls (Figure 2D G and Fig. S1 A H).
The Cd concentrations were lower in the renal medulla compared to the renal cortex and the liver, and Sr was higher in the renal medulla compared to the liver.
However, the apoptosis we observed was unevenly distributed in the kidney, the apoptotic index was higher in the medulla compared to the cortex.
Subjective results were supported by the quantitative analysis where PI, WIS, and MTT were significantly lower in the medulla compared to the cortex.
At 19 months of gestation distinctly fewer and smaller antral follicles were observed in the medulla compared to ovaries from younger individuals, with those present being confined to the cortical border, the cortex being typically 375 1125 μm in width.
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In the GTN Group, the intensity of this band was significantly increased in the hypothalamus and medulla, when compared to the control group (Fig. 1).
Furthermore, Hematoxylin/Eosin staining and subsequent assessment of the ratio of thymic cortex/medulla area (C/M) comparing tissue sections of wt and ADAM8−/− mice revealed a reduced C/M ratio for ADAM8−/− thymi (Figure 2C) suggesting an increased medulla content compared to cortical tissue in ADAM8−/− mice.
Thus, for DAB staining we tended to use sections from higher up in the medulla, as compared to immunofluorescence.
The lowest Cd concentrations were measured in the renal medulla when compared to the renal cortex and liver (P < 0.05).
On the other hand, it was noted that relatively higher inhibitory effect of recreational drugs was found in renal medulla when compared to other peripheral tissues, suggesting a mechanism by which recreational drugs abuse may cause urinary tract abnormalities.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com