The expression of EPORm4L (127 mg l−1 of culture medium) was markedly increased in comparison with wild-type rhEPOR (2 mg l−1 of culture medium).
Proliferative activity of cells in stem-permissive medium was markedly enhanced when compared with differentiated cells, whose growth rate reached a plateau stage early after seeding.
Moreover, the optimal redox state in galactose-supplemented medium was markedly higher than that of the parental strain, indicating that increased carbon flux elevated the availability of NADH in our engineered strain [ 18].
Accordingly, accumulation of the released ammonium ion in the medium was markedly reduced in E. coli Δ gadAB compared to WT E. coli or E. coli Δ yneH (Supplementary information, Figure S7).
However, in the serum-free medium, RT112 cells were markedly more sensitive to gefitinib, with 5 μ M decreasing cell growth by 50% and 10 μ M inhibiting cell growth.
In line with our theory, the AIDA scores in the domains "Discontinuity" (high effect size) and "Incoherence" (medium effect size) were markedly higher in the delinquent boys than in the student group.
The morphology of neuron and synaptic structure was impaired; the number of TUNEL-positive cells and the expression of CHOP in hippocampus of diabetic rats and high glucose medium cultured neurons were markedly altered (P < 0.05).
19 Compared with patients from the very-high HDI group, the presentation characteristics of patients from the medium-HDI group were markedly different, with these patients also being more likely to present with unstable angina.
Likewise, Il-6 concentrations were markedly increased in the medium of MLII osteoblasts (Fig 8A).
Indeed, we show that protein levels of Pri2 and Pol1, both containing a Fe-S cluster binding domain, were markedly reduced in cells grown in iron-deficient medium in comparison to iron-replete medium (Fig. 6A).
