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An optimized agarose gel was utilized as in vitro release medium to simulate the subcutaneous environment in a biorelevant manner.
In order to validate the method, helium turbomachinery are investigated and air is used as the substitute working medium to simulate the helium turbomachinery.
To evaluate the feasibility of this micro-pattern for this application, the microbial range of performance was investigated in addition to biofilm studies with and without a mucin-rich medium to simulate the tracheal environment in vitro.
We perform numerical model experiments with the rate- and state-dependent friction in a three-dimensional elastic medium to simulate the SSE recurrence interval changes by the earthquake loading effects.
The sentiment was shared by GameSpot's Greg Kasavin, who was convinced that pinball was an excellent medium to simulate the challenging struggles found in the Metroid series, noting that the game "pulls it off very well" by being faithful to the main series.
To identify genes that may be involved in survival and pathogenesis of A. pleuropneumoniae in the host we used porcine bronchoalveolar fluid as a medium to simulate, in part, the lung environment.
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This turbulence model is used in combination with physical simplifications and a porous medium approach to simulate the reactor behavior.
Lytic activity was observed when cells were resuspended in BHI + C but was reduced in comparison to PBS; however, the lysis in CM, a complex medium designed to simulate GI tract conditions, was more effective.
At each fixed time interval, the release medium was collected and replaced with 4 ml fresh medium so as to simulate sink conditions.
At predetermined time intervals (0.5, 1, 2, 3, 4, 5, 6, 7, 24, 48, 72 hr), 0.5 mL of dissolution medium was collected, and equal volume of fresh dissolution medium was replaced to simulate perfect sink conditions.
Biologically relevant electrolytes (NaCl, PBS, cell medium) were chosen to simulate the physiological conditions.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com