Sentence examples for medium sized spiny from inspiring English sources

These data indicated that UPS dysfunction may precipitate the critical pathology of the vulnerable medium sized spiny neurons in the striatum [9].

Finally, by excitotoxicity, the N-methyl-D-aspartate (NMDA) receptor agonist quinolinic acid (QA) destroy medium sized spiny neuron in very similar pattern to that seen in human HD pathology [33] [35].

The major population of striatal neurons, GABAergic striatal medium-size spiny neurons (MSN) receives massive innervation from the cerebral cortex, and cortical-like structures as hippocampus and amygdala, which exert a powerful glutamatergic excitatory influence.

In order to characterize the neurons that display increased p-ERK after MDMA injection, we used a DARPP-32 antibody, a marker of GABAergic medium-size spiny neurons (MSNs), in drd2-EGFP transgenic mice subjected to the CPP paradigm.

In order to characterize the population(s) of p-ERK immuno-positive neurons seen after MDMA (10 or 30 mg/kg) injection, we subjected drd2-EGFP transgenic mice to the same CPP protocol described above that responded as WT mice (not shown), and then counterstained brain section with a DARPP-32 antibody, a marker of GABAergic medium-size spiny neurons (MSNs).

Our experiments in the MPTP model reveal that CsA affects other relevant mechanisms such as the activation of DARPP-32 in striatal medium-size spiny neurons.

We identified that in the striatum, TAMRA-P42-TAT was largely diffusing within the neurons, including medium-size spiny neurons (DARPP32 positive cells on Figure  3).

We show that overexpression of Crym in striatal medium-size spiny neurons using a lentiviral-based strategy in mice is neuroprotective against the neurotoxicity of an N-terminal fragment of mHtt in vivo.

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