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In these experiments, SHMC achieves an order magnitude speedup in sampling efficiency for medium sized proteins.
To illustrate this idea, we have modified the 3D TROSY HNCO and the 3D CBCA CO NH experiment allowing efficient measurement of one-bond 1DNH, 1DC′N, 1DCαHα, 1DCβHβ, and 1DCαC′ couplings in small to medium sized proteins.
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Recombinant NY-ESO-1 is a medium sized protein with a molecular weight of ∼23 kD which has been used in multiple clinical trials (http://clinicaltrials.gov).gov
The results are displayed instantly for small and medium size proteins.
Get about two bites of protein food every day (a medium sized Snickers has several grams of protein for instance).
Chop one medium sized tomato and one medium sized onion.
I have medium sized sheep.
Band-winged is a medium sized nightjar.
A medium sized bronze and green hummingbird.
In medium sized bowl, blend syrup and eggs.
Overall, medium sized ROH were most common.
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