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The Shapiro-Wilk test is the most robust test of non-normality for small to medium sample sizes [ 55, 56].
The multilocus model is effectively indistinguishable from the single-locus model for small to medium sample sizes, as distinguishing 7.82% from 8.52% of left-handers in the offspring of R × R parents with a power of 80% would require 24,034 parent offspring pairs.
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The observed results suggest that the proposed bootstrap provides a good statistic distribution approximation for medium sample size.
The rule of thumb that samples of 100-200 represent a "medium" sample size is not absolute because model complexity must also be considered [ 76].
First, the case-control studies included in this meta-analysis were of small or medium sample size; thus, they may have low statistical power for investigating final associations.
The loadings for each method factor were constrained equal under the assumption that a method effect should exert a relatively equal influence on all items, but also in order to maximize degrees of freedom given the medium sample size.
Nevertheless, despite the medium sample size, we found a highly significant effect of maternal third-trimester BPb on child IQ at 6 10 years of age with little evidence of selective dropout bias in the descriptive statistics.
Moreover, we checked a potential small sample size bias by a sensitivity analysis of studies with very small (<25), small (25 to 50) and medium (>50) sample sizes.
All methods are found suitable for medium or large sample sizes [ 114].
This finding was confirmed in a simulation study by Wimmer et al. (2013), who recommend the use of BLUP in plant breeding populations with large linkage disequilibrium (LD) extent, small sample sizes, and medium trait heritabilities.
We collected publicly available datasets from journal articles and repositories such as Gene Expression Omnibus (GEO) and ArrayExpress, selecting those with a medium to large sample size (Table 1).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com