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The medium response group consists of 16 genes (19 probes) that show a moderate upregulation (≥2.5- and <10-fold; Figure 2B).
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However, from that time point on, hazard in the lowest responder group rose and at 3 years became very similar to those in the low and medium response categories (Figure 4B).
We classified the upregulated genes in three main groups based on their fold-change at time point 15 (highest value): "high response", "medium response" and "low response" (Table 1 and Figure 2).
While there was no difference between abstinence rates of subjects on placebo and the subjects with either low or medium antibody response, the difference between subjects on placebo (31.3%) and the subjects with a high antibody response (56.6%) was both clinically relevant (25.3% more abstainers in the high antibody response group) and statistically significant (P = 0.004).
The responses were categorized as low (response categories a and b), medium (response category c), and high (response category d).
The responses were categorized as low (response categories a b), medium (response category c), and high (response category d).
The responses were categorized as low (response categories 1 2), medium (response category 3), and high (response category 4).
Functions were scored as 0 (no response), 1 (small response), 11 (medium response) and 111 (large response).
For clarity, medium responses are depicted for only six modes.
Though immunisation with rBAG1 and rSRS4 elicited significantly higher Th1 responses than the medium control group, but the responses were not as significant as that of the group immunised with the rSRS9 antigen.
amplitude responses group delay.
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