In acidic medium, the release rate was much slower; however, the drug was released quickly at pH 7.4.
The effect of the medium on the release rate of epicatechin was also studied.
The increase in pH, ionic strength and buffer concentration of the dissolution medium decreased the release rate.
Dox-loaded TPP-NPs showed sustained release of Dox from nanoparticles and with the decrease of pH in medium; the releasing rate of Dox was increased and the cumulative release of drug was significantly enhanced.
With the decrease of pH in medium, the releasing rate of Dox was increased and the cumulative release of drug was significantly enhanced, thus enhancing its cytotoxicity in the acidic tumor microenvironment.
In the obtained poly 2MBA -grafted biomaterial, poly 2MBA -grafted as a polymeric prodrug that regulates salicylic acid release once in contact with aqueous medium, showing pH-dependent release rate.
Fig. 9 The memory index of natural waters: Cmax and a τrecovery and b τrr of major species in the river (filled squares), SG aquifer (filled triangles), and S aquifer with high release (filled circles), medium release (crossed circles), and low release rates (open circles).
This was achieved because Eudragit E 100 significantly increased the drug release in acidic medium and slightly decreased the release rate at higher pH.
Drug was released rapidly in the initial stage and restricted into the medium at significantly slower drug release rate in the next period.
The HPMC layer suppressed drug release in a medium with a high Na2CO3 concentration, and subsequently increased the drug release rate in a medium with a low Na2CO3 concentration.
