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Indeed, the investigated sulfonamide was a medium potency hCA I and II inhibitor but was highly effective as a hCA IX and XII inhibitor.
All types of activity have been detected, with several medium potency inhibitors (KIs in the range of 34 220 nM), whereas ethoxzolamide and several halogenated sulfanilamides showed stronger potency, with KIs in the range of 11 22 nM.
The drug is a potent inhibitor of CA II, VII, IX, and XII (KIs of 6 56 nM), and a medium potency inhibitor against CA IV, VA, VB, and VI (KIs of 81 134 nM).
Table 1 Primary selection of polygalacturonase-producing isolates on Congo red medium Potency index (D p/D c) Number of isolates D p/D c > 3.5 7 3.5 > D p/D c > 2.0 58 2.0 > D p/D c 78 D p/D c = 0 57.
Medium potency estrogen-progestin therapy, but not medium potency estrogen alone therapy, was significantly more strongly related to lobular than to ductal breast cancer.
We also found significant associations between medium potency estrogen alone therapy and both ductal and lobular cancer, and between medium potency estrogen-progestin therapy and ductal breast cancer.
Similar(6)
A short course of medium-potency topical steroid or an oral steroid burst for swimmers with severe symptoms may be used [74].
These two drugs were predicted to interact with β adrenergic receptor by SEA, and later experiments revealed that they are medium-potency blockers of β1 subtype (i.e., Ki = 4.4 μM for Prozac and 10 μM for Paxil).
Thus all these sulfamides were medium-potency hCA IX inhibitors and were highly effective as hCA XII inhibitors (Table 1).
Furthermore, only clozapine and olanzapine therapy showed consistently and significantly longer treatment duration compared to perphenazine, a medium-potency typical antipsychotic.
Next, we compared the atypicals (singly and combined) with 2 specific typical antipsychotics: (a) perphenazine, a medium-potency typical antipsychotic, and (b) haloperidol with prophylactic anticholinergic agents.
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