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The independent variable was exposure to wildfires in August 2006, with municipalities thus being classified into the following three categories: no exposure; medium exposure; and high exposure.
Thirteen (24%) infants had low exposure to DEHP-containing products, 24 (44%) had medium exposure, and 17 (32%) had high exposure.
The miR-146b level increased by 12.9-fold within 48 h of differentiation medium exposure and remained high for the remainder of the differentiation time course.
Two binary indicator variables characterize the NO2-exposure at three different levels: x1 = 1 if medium exposure and x2 = 1 if high exposure.
The percentages of workers in the internal control, low exposure, medium exposure and high exposure groups were 34.5%, 17.6%, 37.6% and 10.3%, respectively.
The distances to the nearest road were coded into three categories: closer than 75 m (high exposure), between 75 and 500 m (medium exposure), and 500 m or more (low exposure).
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The splines for all the cumulative exposure variables were somewhat J-shaped indicating non-monotonic trends with ORs falling below 1.0 for low and medium exposures and rising above 1.0 at the higher exposure levels (see Additional file 3: Figures S8 S15).
AORs for the association between the very high and medium exposure categories and non-Hodgkin lymphoma were moderate [1.89595% CI: 1.0, 3.4) n = 11 and 1.5 (95% CI: 1.0, 2.2) n = 28, respectively], while AORs for high and low exposure categories were close to the null compared with the unexposed.
The impact of area of residence was assessed for the Inuits (three categories: Living in the capital Nuuk [presumed low exposure], living on the remaining west coast [presumed medium exposure] and living in the north or east coast regions [presumed high exposure]) and the Swedish study population (two categories: west [presumed low exposure] and east [presumed high exposure] coasts).
The summary-effect estimate for low exposure was 1.83 (95% CI 0.75-4.48), for medium exposure 1.67 (0.86-3.24), and for high exposure 3.50 (0.90-13.2), the latter was based on only one study available.
As exposure to arsenic increased, so did the occurrence of prolonged QTc interval, which was seen in 3.9% of the low exposure group, 11.1% of the medium exposure group, and 20.6% of the high exposure group.
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