In contrast, Sze et al. [9] have shown that the SA technique produced a lower dose at a high dose level (V70Gy) as well as at a low dose level (V20Gy) but a higher dose at a medium dose level (V40Gy) for the bladder when compared with the DA technique.
Studies of probiotics for antibiotic-associated diarrhoea have shown increased effect with higher dose, whereas a study of discomfort symptoms in IBS patients indicated a missing dose response relationship of probiotics, as an effect was observed at a medium dose level and no effects were observed for a lower or a higher dose.
With regards to the pharmacological activities of PPF, anti-inflammatory and CNS suppression effects were observed at all doses, whereas reduction of blood pressure and analgesic effects were shown at high dose and antipyretic effect was shown at the medium dose level of 2,000 mg/kg body weight.
At low, medium and high dose levels, effects can differ not only quantitatively but also qualitatively.
The maximum tolerated, medium and low dose levels of PPF, were 4,000, 2,000, and 1,000 mg/kg body weight.
AL exhibited significant (p < 0.01) activity only at a high dose level whereas CUR exhibited significant activity at medium and high dose levels.
IL-6 and MCP-1 levels were significantly elevated on day 1 at medium and high dose levels, but returned to basal levels by day 7 and remained at basal levels on day 30.
Explants of lung from 1 month old inbred BALB/c mice were cultured in vitro for 4 days with 3-methylcholanthrene added to the culture medium at various dose levels.
However, in comparison with the f-SA technique, the p-SA technique was better in sparing of the rectum and bladder at high, medium, and low dose levels in this study.
