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We compared the risk of fracture in the high and medium dose groups with that in the low dose group.
Meanwhile, levels of renal Epo mRNA in the low and medium dose groups were not significantly different from controls, but were 110% higher with high nitrate compared with controls (P < 0.01; Fig. 3 F ).
Plasma nitrite was not elevated in the low or medium dose groups, but was 1.8-fold (P < 0.01) higher in the high dose group compared with controls (Fig. 3 B ). Finally, circulating nitroso species were not significantly different across the 4 groups, although they trended upward as dose increased (Supplemental Fig. 2 A ).
As shown in Figure 7(a), at 18 h and 66 h after the first drug administration, there was highly significant difference in the swelling degree between the high and medium dose groups (P < 0.01), and the swelling degree for the medium dose group was lower than that for the low dose group but with no significant difference (P > 0.05).
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The mice were injected with 200 μl of FMNPs with the concentrations of 0 mg/ml (control group), 0.1 mg/ml (low dose group, LD), 0.3 mg/ml (medium dose group, MD), and 0.5 mg/ml (high dose group, HD).
The mice were injected with 0 mg (control group), 0.1 mg (low dose group, LD), 0.25 mg (medium dose group, MD), and 0.4 mg (high dose group, HD GOO per mouse.
5 participants (3 in the low dose group and 1 in the standard dose group and 1 in the medium dose group) had 2 SAE-specific hospitalizations.
As such, the medium dose group was equivalent to that received by the nitrate-supplemented normoxic group in the hypoxia study.
However, when compared with integration group, there was significant difference of LDL value in AEE high dose group (p < 0.05) and HDL value in AEE medium dose group (p < 0.05).
After adjustment, all-cause mortality or cardiovascular hospitalization was significantly reduced in the 10 mg dose group compared with placebo (HR 0.75, 95% CI: 0.63 0.90) which was similar to the medium dose group (HR 0.73, 95% CI: 0.52 1.02).
A total of five (29.4%) individuals in the high-dose group had an AGS of 100, versus 2 (6.1%) and 20 (14.3%) in the low- and medium-dose groups respectively.
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