Small adsorbent particle size with its large surface area exposed and highly porous structure lead to a better soaking of drug and more contact with dissolution medium, which also increases the CC dissolution rate (Krstić et al. 2015).
In contrast, CUR@PVP nanofiber showed a drastic increase in their dissolution rate, and the medium in the dissolution flask was yellow, indicating the presence of a stable neutral form due to the formation of a high-energy amorphous phase, as supported by the XRD data.
The limited number of cells per flask and the slow dissolution rate in a large volume of nutritive medium are obvious restricting factors.
Although the consistency of the gel improved after 30 and 60 min, respectively, these gels seemed to be weaker in consistency compared to E3. Drug release studies were carried out in USP type II dissolution rate test apparatus using SGF (pH 1.2) as dissolution medium at 37 ± 0.5°C.
According to Noyes–Whitney equation, the dissolution rate is proportional to the surface area exposed to the dissolution medium [14].
The dissolution rate of OCP, estimated by the phosphate concentration in the culture medium, was the highest in S-OCP, followed by I-OCP and L-OCP, while the specific surface area of OCP decreased.
According to Noyes–Whitney equation [34], the solid dissolution rate is directly proportional to its surface area exposed to the dissolution medium.
where dC/dt is the dissolution rate, D is the solute diffusion coefficient, V is the volume of the dissolution medium, h d is the diffusion boundary thickness, S is the surface area of the solute, C s is the saturation solubility of the solute, and C t (t) is the bulk solute concentration.
Moreover, the paper proposes an alternative way of assessment of AISI 304 SS dissolution rate during intergranular corrosion based on approximation to theory of iron dissolution in sulfuric acid medium.
The dissolution rate of the oxide film was found to increase with increase in the pH of the dissolution medium.
