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The percentage of patients with hypertension was 6% lower in patients with high vs. medium disease burden (Fig. 1b).
The percentage of patients with morbid obesity or depression was 14% and 17% higher, respectively, in patients with high vs. medium disease burden (Fig. 1b).
Of the 12 patients studied; 3 had erosive MTP joints; 10 were treated with DMARD agents; 3 had high disease (DAS28 >5.1); 5 medium disease (DAS28 >3.2 ≤5.1); and 4 low disease (DAS28 ≤3.2).
The mean disease activity of the patients was 35 on a scale of 0 100, calculated using the impairment sum score according to Oerlemans [ 23], representing a low to medium disease activity.
Mean high-sensitivity C-reactive protein (CRP) was almost four times higher in the high vs. medium disease burden groups (32·7 mg L−1 vs. 8·7 mg L−1).
Patients were divided into three groups based on their disease activity score (DAS) 28: those with DAS 28 scores of 3.2 or less were considered to have low disease activity (DAS1); patients with DAS 28 scores of 3.2 to 5.1 were considered to have medium disease activity (DAS2); and patients with DAS 28 score of 5.1 or more were considered to have high disease activity (DAS3) [ 13].
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We found a rebound of disease in 43 patients (28.6%), with a 17 months medium disease-free period.
Patients in the 'single agent' group had low or medium risk disease according to the Charing Cross modification of the WHO GTT scoring system (World Health Organization Scientific Group, 1983) used to stage this disease and received methotrexate and folinic acid (MTX/FA).
Table 2 presents the distributions of POPs by biological medium and disease status for each of the cohorts.
This threshold was selected based on data from large prospective datasets [ 26], demonstrating that it is indicative of the range between low and medium risk disease.
However, these two studies show that DAT SPECT imaging at medium-long disease duration (4.1 to 7.9 years) is able to detect nigrostriatal cell loss [46,47].
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