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Response surface methodology (RS M based on central composite design (CCD) was used to optimize optimal levels of medium compositions.
Also, differences in kinetics may be caused by medium compositions.
Response surface methodology was used to optimize medium compositions (soluble starch, yeast extract and inorganic salts).
Furthermore varimax score models in terms of extraction medium compositions are simpler to interpret.
Persson et al. (1990) also studied the influence of medium compositions on biosurfactant production in P. fluorescens.
There is usually a relationship between the medium compositions and secondary metabolites (Azma et al. 2011; Elibol 2004).
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Experimental designs were practiced for optimisation of the medium composition.
First, the medium composition was optimized in shake flask cultures.
Eleven factors, medium composition and some cultural conditions, were screened.
The variation of the medium composition and fermentation conditions also successfully improved the erythromycin productivity [5],[6].
Hence, optimization of medium composition is vital (Kirk et al. 2002).
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