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In addition, analysis of precision-recall plots (Figure 2) showed that, initially, all models occupied the region of medium classification effectiveness with high recall and low precision (quarter IV).
The default annotation category for biological processes of GO (GOTERM_BP_FAT) and the medium classification stringency settings were selected.
For the gene functional annotation clustering, the Database for Annotation, Visualization and Integrated Discovery (DAVID), fifth version (http://david.abcc.ncifcrf.gov/gene2gene.jsp) was used, with the default parameters at medium classification stringency.
To assess whether the differentially expressed genes are related to development and organogenesis, we classified the 1011 differentially expressed genes into gene ontology (GO) groups using DAVID (Database for Annotation, Visualization and Integrated Discovery) with medium classification stringency.
Medium classification stringency was used.
When performing the classification analysis, we applied the medium classification stringency, implemented Benjamini multiple testing correction and set the threshold value of Enrichment score at 1.0 [ 34].
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The homozygous minimal medium classifications were used in this analysis to allow identification of knockouts that do no affect growth even when no copies are present and growth conditions are less favorable.
Thus, signals from neighboring cells of the same cell type do not increase the i-th cell's inner state, while signals from different cell types increase the i-th cell's inner state and both cavity and medium classifications increase the i-th cell's inner state even more.
This type of structure is more clinically useful in the approach to a patient than the simple "high, medium, low" classification that we obtained in the analysis of the descriptors.
Rather, it is more appropriate to consider the results of this analysis as sufficient to support only semiquantitative (low, medium, high) classification of phase-specific RBA values.
High skill includes college and junior college graduates, and top and middle managers (groups 1 to 6 in the Social Security classification), medium skill includes administrative assistants and so-called first- and second-level officers (groups 7 and 8), and low skill includes third-level officers and unskilled workers (groups 9 and 10), see García Pérez (1997).
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