Sentence examples for medium affinity from inspiring English sources
The obtained affinity constants indicated that the investigated McAb was an antibody with medium affinity.
Highest titers were observed with one particular DARPin binding to the membrane distal domain of HER2/neu with medium affinity.
For the first (E1) and the second (E2) eluted PRO enantiomers the results were: 1 1 stoichiometry, medium affinity constants, log KE1 = 3.20 ± 0.16 and log KE2 = 3.40 ± 0.14, medium protein binding percentage, PB = 48.7 and 60.1% for E1 and E2, respectively, and moderate but significant enantioselectivity, ES = KE2/KE1 = 1.5 ± 0.3.
Thus, in this in vitro system, both peptides bind with medium affinity (µM range) to HSC70.
For example, pri-miRNA-34a showed a high affinity towards hnRNPH1 but only a medium affinity to hnRNPR whereas pri-miRNA-21 had a low affinity towards hnRNPH1 and a medium affinity towards hnRNPR.
The calbindin-D28k model had four independent calcium binding sites, two of medium affinity and two of high affinity (Table 1).
The PDZ domains of syntenin bind to multiple peptide motifs with low-to-medium affinity [ 8, 9], are essential for assembly and organization of diverse cell-signaling processes occurring at the plasma membrane [ 6, 10].
Our findings should be confirmed in larger samples, which could also include medium-affinity binders to assess the impact of genotype on longitudinal variability.
This point is of crucial importance, because the time elapsing between binding of synthetic peptides and engagement with T cell precursors in secondary lymphoid organs may well exceed the peptide life span at the MHC binding groove, especially for low- to medium-affinity peptides [78].
To better relate GECI fluorescence to changes in [Ca2+], we performed additional experiments in which we simultaneously measured responses from the GECIs and from the medium-affinity synthetic red calcium dye X-Rhod-5F, loaded through the patch pipette (Figure 4D).
