For the sake of biological and medicinal studies, the region of interest is neutral pH between 5.5 and 7.5, where is plateau.
Inclusion criteria: studies that focused on participation or non-participation in clinical medicinal studies of adult women with breast cancer.
Expression quantitative trait loci (eQTL) were detected first in medicinal studies in humans and later also in plants [ 6– 10].
This review includes both qualitative and quantitative studies that discuss reasons and barriers or influencing factors for the participation of female breast cancer patients in medicinal studies.
Twelve publications were excluded as secondary literature, comments or protocols; 17 publications were excluded because their focus was not of interest (e.g., medicinal studies).
Clinical medicinal studies in this paper, are defined as studies with a variety of medical therapies, which may include, for example, chemotherapies, endocrine therapies and immune therapies within neo-adjuvant and adjuvant therapy [ 9].
Despite a lack of data material, it was possible to identify various factors influencing women's willingness to participate in medicinal studies and group them into three categories: person-related, study-related, and physician-related.
To gain a better understanding of why especially female breast cancer patients frequently do not participate in clinical medicinal studies, a systematic review regarding this sensitive female patient group was conducted.
Yeast Saccharomyces cerevisiae is a simple and readily manipulable organism that has been successfully used as a model for various medicinal studies (reviewed in [ 9, 10]), including neurodegenerative disorders, associated with the deposition of amyloid aggregates [ 11- 18].
