Sentence examples for medicinal chemistry methods from inspiring English sources

Like many medicinal chemistry methods, this involves a lot of generating and evaluating molecules.

We also discuss the current possibilities to overcome drug resistance by using a molecular mechanistic approach based on medicinal chemistry methods focusing on rational structural modifications of novel antitumor agents.

Subsequent to the preparation of a less-potent but more flexible lead, classic medicinal chemistry methods were applied to restore high affinity (compound 22, CGRP Ki = 0.035 nM) while maintaining structural diversity relative to the lead.

Here, the same methodology was applied to establish the relationships between solvent-solute interactions, determined empirically, and the ADMETox end points of a larger number of the hydantoin derivatives, obtained by established computational medicinal chemistry methods.

Primary reasons for discussing the different aspects and applications of SARMs in context have been to expose this approach to a wider drug development audience and provide an example for the data- and application-driven evolution of a computational medicinal chemistry method.

In silico tools used in medicinal chemistry include chemometric methods, structure activity relationships (SAR), mole cular modeling, and quantitative structure activity relationships (QSAR), which correlate the structural or property descriptors of compounds to several types of biological activities.

A great challenge in medicinal chemistry is to develop different methods for structural design based on the pattern of the previously synthesized compounds.

Practical skills such as the mastery of design tactics or parallel chemistry methods help the medicinal chemists efficiently navigate a pathway through hypothesis space.

Through the combined use of modern molecular biology, transgenic animal models, and other more traditional research methods such as medicinal chemistry and classical pharmacology, a clearer picture of the role of serotonin and its receptor subtypes in mnemonic processes is beginning to emerge, however.

Professor of Medicine, Pharmacology and Medicinal Chemistry.

Methods and Principles in Medicinal Chemistry v34.