No side effects associated with trial medication were detected during the study, other than increased rectal temperature in ABT-116 group.
However, due to well developed health screening and occupational health care system in Finland, we can be fairly certain that most cases entitled to reimbursement of diabetes medication were detected in our study.
Follow-up was terminated if patients had at least two/three or more consecutive missing data points (corresponding to an absence of at least one month) and if antimalarial self-medication was detected by interview or metabolite assay.
Increased intraocular pressure (IOP), which was controlled with additional medication, was detected in 15 of 58 eyes (25.9%).
In total, 449 medication errors were detected throughout the medication use process, involving 341 prescriptions (Table 3).
36.27 % observations (230) included some type of error, a total of 245 medication errors were detected.
An overview of the actual medication use in the study population (which reflects comorbidities) according to the ATC classification is given in online supplementary appendix A. Overall, 342 medication errors were detected in 211 patients with an eGFR ≤40-alert (15% of the study population) (figure 1).
However, other than age and HT medications, no significant differences were detected in patient characteristics among groups, and the multivariate analysis revealed that ACEI/ARB use remained a significant prognostic factor for both PFS and OS, though we cannot fully correct the bias that patients with HT were much older than patients without HT.
Some conditions were better detected using prescription medication monitoring, while others were detected using previously inputted diagnostic codes.
As previously mentioned, in preclinical studies, QT interval prolongation and ST segment abnormalities were observed in Beagle dogs treated with rapid infusions of the medication, and cardiac hemorrhages were detected on autopsy when lethal doses were administered.
