During the sampling procedure, children with comorbid medical disorders or ongoing medication were excluded from our sample.
Ongoing medical, neurological, or psychiatric disease (including depression), and current use of psychotropic medication were excluded through an individualized interview with an experienced clinician (R.V. or P.B .. Depressiveness was assessed with a computerized German Version of the Centre for Epidemiologic Studies Depression Scale (CES-D, [68]; German Version: [69]).
Children with chronic disease or immune suppression due to medication were excluded from participation.
Participants who had taken any antidepressant medications during their current MDD episode as well as those with a history of treatment non-response (2+ failures of an adequate trial of a standard antidepressant medication) were excluded from participation.
Participants with prophylactic headache or other prophylactic pain medication were excluded (n=209).
Patients with chronic migraine or overuse of analgetics and other acute migraine or pain medication were excluded from the study.
Participants with a known history of psychopathology and those who were taking medication were excluded.
Individuals using lipid lowering medication were excluded from the analyses of lipid variables, and individuals using drugs for hypertension were excluded from the analysis of blood pressure.
Subjects using lipid-lowering medication were excluded.
Women using antidepressant medication were excluded.
Subjects taking CNS-acting medication were excluded.
