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Dosages and timing of study medication were determined using data from previous studies [ 1, 17- 19]; the first administration of each agent was 30 minutes before bacterial challenge.
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Fourth, although no significant intergroup differences in the use of various CV drug classes during the follow-up period were detected, the type of medication was determined exclusively by the analysis of an available medical documentation.
In the absence of coherent European guidance on the treatment of PACS in the community, the use of rescue medication is determined locally and is subject to substantial variation.
At enrollment, screening assessments (with the exception of demographics) were re-performed; DFN-02 devices (individually blister packed and labeled), an Instructions for Use document, and a paper diary were dispensed; and rescue medication was determined.
The index date of each medication was determined according to the first dispensation date of each specific medication.
Opinions about and subjective experiences with medication was determined by the Morisky [ 43] and the Drug Attitude Inventory (DAI-10) [ 44].
The persistence of these deficits despite adequate dopaminergic medication was determined clinically, including by examination in a practically defined ON medication state.
The proportion of participants who met the ABC target goals and the use of statin medication was determined by demographic characteristics and diabetes-related factors.
The generic status of each antihypertensive medication was determined from the U.S. Food and Drug Administration FDAA) website (www.fda.gov) by identifying the approval date for the marketing of one or more generic products containing that specific antihypertensive medication or combination of medications.
A true positive of a matched medication was determined if and only if the algorithm returned a "matched" label and the medication was matched to the same prescription as identified by the annotators.
With regard to direct biological factors, the efficacy and toxicity of a medication are determined by the balance between its pharmacokinetics (absorption, distribution, metabolism and elimination of the drug) and its pharmacodynamics (the physiological effect of the active drug at the site of biological action).
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