For example, tailored interventions may target timing of behaviors such as medication usage or variability in symptoms by time [ 34].
Finally, the study is strengthened by the adjustment for other factors which are well known confounders of vision-related quality of life in an ageing population, such as medication usage, co-morbidities including other ocular conditions and wearing glasses.
Overall, we aimed to capture a representative sample of stroke patients which would typically include those who engage in behaviour that can contribute to changes in physiological arousal such as medication usage but are not directly related to their stroke per se.
Epidemiological studies indicate that older adults who are more depressed have an increased risk of falls and fractures compared to their aged-matched peers and that this association persists even after adjusting for potential confounding effects such as medication usage [ 3- 5].
There are, however, potential confounding factors that might account for these findings, such as the medication usage in these cohorts.
Secondary RLS has been associated with other medical conditions and medication usage.
The two cohorts were otherwise similar in demographic composition, medical comorbidities and medication usage at inclusion.
Due to incomplete records on the specific targeted therapy usage, such as duration of medication or drug dosage, we were unable to incorporate detailed information in our analysis despite their potential effects on survival.
Participants were screened to exclude psychiatric or systemic medical disorders and current medication usage.
Sociodemographic and medical information such as age, sex, race/ethnicity, education level, household income, and medication usage were collected during the household interview.
Second, we were not able to evaluate non-environmental sources of biologic variability such as changes in diet, health status, or medication usage.
