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Subjects were excluded if they had diabetes, were using a medication that affects weight or glucose metabolism, or had a medical condition that precluded program participation.
As part of sensitivity analyses, all tests were repeated in each of the following subgroups for each timepoint and then for the whole study: excluding subjects taking anti-inflammatory medication; excluding all medication that affects CRP; excluding outliers, defined as CRP values above 10 mg/L.
None of the subjects was taking any medication that affects bone metabolism.
Platelets were obtained from healthy volunteers not taking medication that affects platelet function.
Exclusionary criteria included inability to perform the 6 min walk test and medication that affects cognitive function or heart rate, such as prescription beta blockers (see Table 1).
Botulinum toxin type A should not be used in subjects with a bleeding disorder and used with care in patients taking medication that affects clotting.
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An electrocardiogram recording was repeated at all visits if the pretherapy/entry QTc was ≥ 500 ms or if the subject was taking a concomitant medication that affected cardiac conduction.
The website identifies the primary reason for this revision as the view that the term "dependence" is misleading: We are urged to not confuse the fact that tolerance and withdrawal are normal responses to some prescribed (read: medically necessary) medications that affect the central nervous system, and thus these physical states should not be seen as an illness.
A careful medical history, noting medical conditions and medications that affect colonic transit should be conducted (Table 1).
Any participant who developed an illness during the study that required treatment with steroids or medication that affected bone, inflammatory and other metabolic markers was also excluded.
This review systematically identifies studies reporting on formulation aspects of oral medications that affect their acceptability in these patient groups.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com