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In Parkinson's disease, gait freezing becomes more common and less medication responsive with disease progression (Giladi et al., 2001; Bloem et al., 2004).
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Medication-responsive patients may cease to respond over the long term if they cycle on and off the medications; with each episode, there is a ten-per-cent increase in the risk that the depression will become chronic.
Evaluation of medication-responsive subjects is left for a future study.
Medication-responsive control subjects likely represent a distinct group from healthy non-depressed controls and must be treated differently.
There was no treatment-related normalization for cytokines IL6 and TNF or for two of the neuroplasticity genes among the medication-refractory depressed patients, while medication-responsive patients did show normalization in all of these except TNF.
Given the complex post-transcriptional processing of APP, future studies should combine mRNA and protein analysis to determine the relationship between APP transcript levels and peptide products, and if levels differ between medication-refractory and medication-responsive patients.
In Parkinson's disease, freezing of gait/postural instability becomes more common and tends to be less medication-responsive as the disease progresses (Giladi et al., 2001; Bloem et al., 2004).
We enrolled 51 consecutive patients (age range 24-65 years) with a chronic headache who satisfied 1 or more of the following conditions: 1) failure of at least 2 prophylactic treatments; 2) medication overuse non-responsive to at least 2 properly conducted protocols of detoxification; 3) medication overuse relapsed at least twice after successful detoxification.
Similar to our results, no significant difference was found in the number of OTC medications used by responsive versus unresponsive patients.
In addition, approximately two-thirds of enrolled children (and all participants in the 1-year study) were previously untreated with ADHD medications and therefore may have been more responsive to medication than children who had received, but failed, prior treatments.
Negative symptoms are deficits of normal emotional responses or of other thought processes, and are less responsive to medication.
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