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As discussed in the previous paragraphs, different supportive medication regimens have been proposed.
Reasons for nonadherence to medication regimens have been shown to be complex and multifactorial [ 4- 7], but the high daily tablet burden associated with most phosphate-binder medications may be a contributing factor [ 8, 9].
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Patients' adherence to their medication regimens has been reported to be influenced by the interaction of number of factors [ 8].
Reducing the complexity of medication regimens has been found to be one of the most effective measures to improve adherence [ 16, 17].
Current medication, age and comorbidities were evaluated to determine if their current medication regimen had scope for improvement.
Similarly, patients reporting low adherence to their medication regimen had lower odds of reaching target blood pressure.
Compliance with the medication regimen has improved after 12-months follow up (p = 0.003), unlike smoking status or physical activity practice (Table 3).
It is well established that corticosteroids can improve quality of life in metastatic CRPC patients (Tannock et al, 1996); however, it is unlikely that differences in corticosteroids pre-medication regimen have had a significant impact on the palliative outcomes in the D/EPI arm, as patients in the D/P arm received also continuous oral P 5 mg twice daily.
The latter, more simple medication regimen may have advantages with regard to adherence and minimization of side effects.
Although patients were screened for nonadherence to their medication regimen, 11% had no detectable resistance mutations.
A study of patients aged 65 years of age or above found that 62% showed understanding of their medication regimens but those with the most complex regimens had difficulty with naming and explaining the purpose of their medications [ 4].
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