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A further three studies had a measure of medication persistence as the adherence outcome obtained from patient medical records [ 86– 86].
Although copayment cost has been implicated as a factor influencing medication persistence, it remains unclear whether reducing or eliminating these costs can improve medication persistence and/or downstream clinical outcomes.
CONCLUSION: ARTEMIS will be the largest randomized assessment of a medication copayment reduction intervention on medication persistence, clinical outcomes, treatment selection, and cost of care after acute MI.
DESIGN: ARTEMIS is a multicenter, cluster-randomized clinical trial designed to examine whether eliminating patient copayment for P2Y12 receptor inhibitor therapy affects medication persistence and clinical outcomes.
BACKGROUND: The use of oral P2Y12 receptor inhibitors after acute myocardial infarction (MI) can reduce risks of subsequent major adverse cardiovascular events (composite of all-cause death, recurrent MI, and stroke), yet medication persistence is suboptimal.
The use of oral P2Y12 receptor inhibitors after acute myocardial infarction (MI) can reduce risks of subsequent major adverse cardiovascular events (composite of all-cause death, recurrent MI, and stroke), yet medication persistence is suboptimal.
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By medication class, persistence was also high, ranging from 83% for warfarin, 95% for antihypertensives and lipid-lowering medications, and 100% for antiplatelet therapy and diabetes medications.
Foley et al. also found a close relationship between sedative medication and persistence of insomnia symptoms over 3 years in an elderly population in the community [ 13].
Medication non-persistence is associated with poorer outcomes, greater likelihood of re-hospitalization and increased mortality [ 22, 23].
GLOBAL accounted for more variance than did the more specific TSQM scales and was the most significant independent variable accounting for medication non-persistence (standardized Beta coefficient = -.35, p <.0001).
Over the next 6 months, he was intermittently compliant with medications, had persistence of the lower extremity edema and was sent to the emergency room (ER) when, on one of his follow-up visits, he was found to be severely hypertensive with advanced renal failure.
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